Mass Spectrometry & Spectroscopy
New Bioreactor for Stem Cell Derived Hollow Organ Generation
Feb 27 2012
Harvard Apparatus in conjunction with Dr Paolo Macchiarini,has developed the InBreath Whole Organ Bioreactor.
The InBreath is one of the world's first commercially available bioreactors for tubular organ regeneration. Designed for tissue engineering and regenerative medicine research applications using trachea, esophagus, intestines, blood vessels or virtually any hollow organ, the InBreath is precision engineered for cell seeding and culturing on both intraluminal and extraluminal surfaces of a tubular matrix.
A polymer-based culture chamber houses the scaffold and culture medium for the entire duration of the organ generation procedure. An organ scaffold is mounted to the corresponding scaffold holder of appropriate diameter. Each holder features a reduced diameter central portion which functions to expose the intraluminal surface of the matrix for cell seeding and culturing.
Secondary elements or ‘paddles’ moving with the scaffold holder produce continuous mixing of the culture medium to
increase oxygenation and mass transport. The cell/scaffold construct is rotated on the holder by a brushless DC motor (0-5 rpm adjustable), which is completely separated from the culture compartment.
A co-axial conduit links the inner chamber to the external environment through an interface at the chamber wall. The
detachable connection between the motor unit and the culture chamber allows the latter to be removed for maintenance while the motor unit remains stationed in the incubator. An external control unit regulates and monitors rotation. Autoclavability, ease of handling under sterile conditions, reliability and precision ensures full compatibility of the device with GLP rules.
Digital Edition
LMUK 49.7 Nov 2024
November 2024
News - Research & Events News - News & Views Articles - They’re burning the labs... Spotlight Features - Incubators, Freezers & Cooling Equipment - Pumps, Valves & Liquid Hand...
View all digital editions
Events
Nov 11 2024 Dusseldorf, Germany
Nov 12 2024 Cologne, Germany
Nov 12 2024 Tel Aviv, Israel
Nov 18 2024 Shanghai, China
Nov 20 2024 Karachi, Pakistan