Single-use Bioreactors for Large-scale Cell Culture Production Launched

The Thermo Scientific HyPerforma DynaDrive S.U.B.is now available in 3,000 L and 5,000 L models. The first-of-its-size 5,000 L S.U.B. is Thermo Fisher Scientific's largest commercially available S.U.B., enabling biopharmaceutical companies to integrate single-use technologies into large-scale bioprocesses, including perfusion cell culture and cGMP manufacturing at very high cell density.

The DynaDrive portfolio, including the 50 L, 500 L and now expanded to 3,000 L and 5,000 L S.U.B.s, offers features that support cell culture performance across scales and accommodate high-density and next-generation cell culture processes. DynaDrive S.U.B.s also provide superior turn-down in stirred tank reactors, reducing the number of vessels required for seed-train scale-up. By minimising seed-train and enabling large-scale, high-intensity processes, the DynaDrive S.U.B.s reduce overall costs ;through reduced capital investment, reduced operational expenses, and higher-output processes.

Thermo Fisher launched its S.U.B. portfolio in 2006 and was the first supplier to launch a 2,000 L S.U.B. in 2011. The DynaDrive ;50 L and 500 L models were launched in 2020 and introduced new features, including a unique impeller design, patented cross-flow ;sparger technology and improved sensor technology. Thermo Fisher's DynaDrive S.U.B.s are designed to deliver superior performance in single-use format and increased scalability for cell culture processes.

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