Single-Use Bioreactor for Cell Culture Production Launched

The HyPerforma DynaDrive Single Use Bioreactor (S.U.B.) from Thermo Fisher Scientific delivers improved performance and scalability for larger volume cell culture processes. After launching a 50 L DynaDrive S.U.B in September 2020, Thermo Fisher has released the next-in-class size DynaDrive S.U.B. with capacity of 500 L with future options for scalability to 5,000 L.

As biopharmaceutical companies increasingly integrate single-use-technology into new processes such as perfusion and cGMP manufacturing, they are seeking scalable single-use bioreactors. The DynaDrive S.U.B. offers superior scale and power compared to other solutions available, while also reducing capital investment and operational expenses due to reduced seed-train and scale-up processes.

The unique shape of the unit and BPC, the design of the impeller, sparging approach and the improved sensor technology are just a few of the features that were redesigned in order to optimise mixing dynamics, scale, and performance. The new cubical geometry and design provides baffles in corners and better bioprocess container (BPC) fit.

Mixing times, power input per volume (PIV), and kLa performance are easily capable of supporting viable cell densities of >100 million cells/mL. The drive train is integrated in the HyPerforma DynaDrive BPCs, which are made with highly robust Thermo Scientific Aegis 5-14 bioprocessing film.

The minimised size of the hardware, which is optimised for perfusion cell culture processes, helps save precious lab space.  20:1 turndown ratio enables running the 500 L bioreactor in as low as 25 L working volume for seed train.

The streamlined dataflow is built with TruBio software and powered by the DeltaV automation platform.

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