New DNA-chip for Genotyping HPV

Greiner Bio-One GmbH, has recently launched PapilloCheck®, a DNA-chip for the simultaneous genotyping of 24 different types of human papilloma virus (HPV). The biochip is an In-vitro diagnostic tool for the qualitative detection of human papilloma viruses in clinical specimens.

Since a persistant infection with HPV is regarded as the main cause of nearly all cases of cervical carcinoma, PapilloCheck® opens up new possibilities for the successful diagnosis, therapy and research investigation of cervical cancer disease.

The genotyping of 18 so-called high-risk (hr) as well as 6 low-risk (lr) HPV-types with PapilloCheck® is based on the hybridisation of the virus-DNA on DNA-arrays. The described HPV-types are detected in parallel in a single assay. HPV-typing with PapilloCheck® permits a more targeted evaluation of the risk of the infection, because hrHPV- types themselves show a different risk potential for the occurrence of a cervical carcinoma. In addition, PapilloCheck® offers a precise basis for the management of HPV-vaccinations as well as for epidemiological studies.