• 
Cell Alteration Could Fight Inflammatory Diseases

News & Views

Cell Alteration Could Fight Inflammatory Diseases

Oct 25 2012

A fundamental mechanism controlling cells of the human immune system could be key to helping fight inflammatory diseases such as rheumatoid arthritis and psoriasis, new research at the University of Dundee has found.

The research by Dr Kris Clark, in the Medical Research Council Protein Phosphorylation Unit (MRC-PPU) at Dundee, concentrated on the activity of macrophages, which are cells of the immune system that defend the body against infection by bacteria and viruses.

Dr Clark found that an enzyme called SIK is active in suppressing the production of anti-inflammatory molecules. By `switching off’ the function of SIK within the cell, he was able to greatly enhance the production of beneficial anti-inflammatory molecules.

The research suggests that drugs that switch off SIK may improve current therapies for treating inflammatory diseases, such as rheumatoid arthritis and psoriasis.

“These are very exciting times for our research,” said Dr Clark. “This discovery represents the first link between SIK and inflammation. My immediate future goal is to characterize in more detail the roles that SIK plays in the immune system and how they are affected by compounds that switch off this enzyme.”

Working with the Drug Discovery Unit at Dundee, Dr Clark has now started to develop molecules which could provide the basis for drugs to turn off SIK.

“My studies have greatly benefitted from working in the multi-disciplinary and collegial environment that has been built up in the MRC Unit, the Scottish Institute for Cell Signalling and the College of Life Sciences at Dundee,” said Dr Clark. “My interactions with the scientists who work here and the advice they have given me has not only been invaluable for this project, but also most enjoyable.”

The research has been published in the Proceedings of the National Academy of Sciences of the USA.


 


Digital Edition

LMUK 49.7 Nov 2024

November 2024

News - Research & Events News   - News & Views Articles - They’re burning the labs... Spotlight Features - Incubators, Freezers & Cooling Equipment - Pumps, Valves & Liquid Hand...

View all digital editions

Events

MEDICA 2024

Nov 11 2024 Dusseldorf, Germany

FILTECH

Nov 12 2024 Cologne, Germany

Intech

Nov 12 2024 Tel Aviv, Israel

analytica China

Nov 18 2024 Shanghai, China

Pharma Asia

Nov 20 2024 Karachi, Pakistan

View all events