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Protein found to regulate spread of pancreatic cancer cells

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Protein found to regulate spread of pancreatic cancer cells

Aug 12 2012

Protein found to regulate spread of pancreatic cancer cells
Researchers at Queen Mary, University of London have identified a new protein that makes pancreatic cancer cells less ‘sticky’ and therefore less able to attach to and invade other tissue.

The protein, known as S100PBP, does this by suppressing a second protein called cathepsin Z. The research team has shown that cathepsin Z makes pancreatic cancer cells sticky, allowing them to spread to their surrounding environment. Prior to this study nothing was known about the function of S100PBP in the body or the role that cathepsin Z plays in pancreactic cancer.
The findings, funded by the UK charity, Pancreatic Cancer Research Fund (PCRF), are reported in The American Journal of Pathology.

Lead researcher Dr Tatjana Crnogorac-Jurcevic of Barts Cancer Institute at Queen Mary said: “We believe these findings are significant. A greater understanding of the role these proteins play in the adhesion and spread of pancreatic cancer to other organs, which is almost always the case in this deadly cancer, could help us to develop novel preventive and therapeutic targets.”

Pancreatic cancer has the worst five year survival rate of any common cancer – 3 per cent - and this figure has not improved in forty years. With no early diagnostic test available, and symptoms that are often mistaken for less serious conditions, the majority of sufferers are diagnosed too late for surgery - currently the only possible curative option.
 


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