Advion Launches Cost-effective, Bench-top Solid Phase Peptide Synthesis and Protein Characterization Mass Spectrometer

Advion, Inc., a leading systems and consumables developer for the life sciences industry, announced during the ABRF 2016 Annual Meeting in Fort Lauderdale, Florida the introduction of a proteins and peptides analysis system, 'TIDES EXPRESS.  The system combines Advion's new, easy-to-use, HPLC system with the extended mass range expressionL compact mass spectrometer (CMS).  The new platform improves the workflow of chemists performing peptide synthesis and needing fast mass analysis of each reaction step as well as final products. It is the perfect technique for monitoring reactions in solid phase peptide synthesizers.  Additional fragmentation analysis and charge deconvolution tools also enhance its use for protein characterization.

Solid phase peptide synthesis (SPPS) allows for rapid, parallel synthesis of peptides of various amino acid (AA) lengths, some of which routinely exceed 30 or 40 in length. Although modern SPPS shows a high degree of automation, some SPPS peptide targets remain challenging to synthesize and a single suboptimal synthesis cycle can cause costly re-runs in large scale or long chain protein production – rapid analysis of each reaction step can prevent this.  Mass spectrometry provides both molecular mass and amino acid sequence information through specific and selective molecule fragmentation along the amino acid backbone.  The 'TIDES EXPRESS includes an easy-to-use HPLC gradient system with manual sample injector, expressionL CMS along with fragmentation analysis and charge deconvolution software tools for easy and excellent data interpretation.

"The complexity of proteins and peptides analysis requires efficient and cost-effective analysis for informed decision making," says Simon Prosser, Vice President of Marketing.  "The ease-of-use and compact size makes the 'TIDES EXPRESS ideal for bench-top reaction monitoring of SPPS systems, most of which to-date have been limited to UV or IR monitoring of analytes."

Advion is now quoting the 'TIDES EXPRESS and deliveries will begin in mid-April.