Laboratory Products
Online Monitoring of Cloud Point Determination
Mar 02 2012
The development of pharmaceutical ingredients requires extensive testing and evaluation. One crucial parameter is the exact determination of the cloud point, the temperature at which the ingredient starts to crystallise. In most cases, the cloud point occurs very abruptly, making this determination difficult. The downside of conventional measurement procedures is that an exact process monitoring cannot be performed in real time. This however can be solved through the use of a special mini process probe from Hellma Analytics that monitors the process online in combination with a spectrophotometer. Even as the first crystal forms there is a significant change of the absorption spectra making an exact determination of the cloud point guaranteed. The mini process probe has removable light path tips with anti-twist protection, thus 100% reproducibility of the results is ensured. Handy dimensions as well as high-quality sealing components make this probe a robust and flexible solution. This mini process probe has FSMA connections and is available with either UV or NIR optical fibres. A modular construction system enables the adaption to various customer requests, for example, the optical measuring component can be produced from quartz or sapphire and different lengths are available.
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