Corning Matrigel Matrix

Cells behave better on Corning Matrigel matrix - the original, trusted extracellular matrix (ECM).

The development of Corning Matrigel matrix, a solubilised basement membrane preparation extracted from the Engelbreth-Holm-Swarm (EHS) mouse sarcoma, a tumour rich in such ECM proteins as laminin (a major component), collagen IV, heparin sulphate proteoglycans, entactin/nidogen, and a number of growth factors.

Corning’s natural ECM-based hydrogel is among the most widely used models for 2D and 3D cell culture in vitro, enabling you to:

Improve the attachment and differentiation of both normal and transformed anchorage-dependent epitheliod cells, as well as other cell types.

Better mimic in vivo environments for 2D and 3D cell culture applications.

Corning Matrigel matrix is effective for the attachment and differentiation of both normal and transformed anchorage-dependent epithelioid and other cell types. These include neurons, Sertoli cells, chick lens, vascular endothelial cells, and hepatocytes.

Applications include:

• Influencing gene expression in adult rat hepatocytes
• 3D culture in mouse and human mammary epithelial cells
• In vivo peripheral nerve regeneration
• Metabolism and toxicology studies
• The development of several types of tumour cell invasion assays
• The in vitro and in vivo study of angiogenesis
• In vivo propagation of human tumours in immunosuppressed mice
• The maintenance of human embryonic stem cells and induced pluripotent stem (hiPS) cells
• Neuronal differentiation of hiPS cells