Chromatography
Toxic Adulterants in Pharmaceutical and Personal Care Products
Oct 05 2010
Dionex is pleased to announce the release of an application that demonstrates the determination of ethylene glycol (EG) and diethylene glycol (DEG) in a sorbitol solution using liquid chromatography with
pulsed amperometric detection.
Application Note 246: Determination of Ethylene Glycol and Diethylene Glycol in a Sorbitol Solution describes two confirmatory methods to determine 0.1% EG and DEG in sorbitol solutions. Glycerin, sorbitol, and propylene glycol (PG) are widely used in pharmaceuticals and personal care products. The adulteration of these pharmaceutical formulations with the less expensive and toxic DEG and EG has been linked to systemic alcohol intoxication, multiorgan failure, and acidosis, leading to hundreds of fatalities. The US FDA proposed a limit of 0.1% DEG and EG contamination in sorbitol and other excipient solutions. The methods described in AN 246 demonstrate the accurate, precise, and direct determination of 0.1% DEG and EG in a sorbitol solution.
Digital Edition
ILM 49.5 July
July 2024
Chromatography Articles - Understanding PFAS: Analysis and Implications Mass Spectrometry & Spectroscopy Articles - MS detection of Alzheimer’s blood-based biomarkers LIMS - Essent...
View all digital editions
Events
Jul 30 2024 Jakarta, Indonesia
Jul 31 2024 Chengdu, China
ACS National Meeting - Fall 2024
Aug 18 2024 Denver, CO, USA
Aug 25 2024 Copenhagen, Denmark
Aug 28 2024 Phnom Penh, Cambodia