Chromatography
Monitoring of Iodine- and gadolinium-containing Contrast Media in Aqueous Matrices
Sep 06 2011
Metrohm is pleased to present a method for the rapid, reliable, and sensitive analysis of free and complexed gadolinium and iodine-containing compounds in aqueous matrices by ion chromatography (IC) and inductively coupled plasma mass spectrometry (ICP/MS). The method proceeds without costly sample preparation and provides substantial information on the entry, degradation, and fate of contrast agents in (waste)water. Biologically inert iodinated X-ray contrast media (ICM) and gadolinium chelates are used as contrast agents diagnostic radiology. These contrast media are applied extensively and are excreted in unmetabolized form via urine into wastewater. ICMs are suspected to be nondegradable in most conventional water treatment plants and ultimately accumulate in drinking water. As their effects on the environment are still unknown, they are removed by water treatment technologies using either ozonation or floculation. Ozonation gives origin to a range of unidentified iodine-containing ozonation by-products (OBPs) of unknown toxicity. Similarly, the addition of competitive Fe3+ ions in the flocculation step enhances the
displacement of gadolinium from its chelate complexes, which gives origin to highly toxic Gd3+ ions. In laboratory studies, the effects of ozonation and flocculation were evaluated, respectively, for iodine-containing (e.g., Iomeprol, Amidotrizoic Acid) and gadolinium-containing (e.g., Gadovist®, Magnevist®) contrast media.
Digital Edition
International Labmate Buyers' Guide 2024/25
June 2024
Buyers' Guide featuring: Product Listings & Manufacturers Directory Chromatography Articles - Enhancing HPLC Field Service with fast-response, non-invasive flowmeters - Digital transformatio...
View all digital editions
Events
Jul 07 2024 Dublin, Ireland
Jul 20 2024 Denver, CO, USA
Jul 21 2024 Cape Town, South Africa
Jul 28 2024 San Diego, CA USA
Jul 30 2024 Jakarta, Indonesia