Brighter Analysis  

Analytical techniques such as Titration, Chromatography, and Spectroscopy are only as reliable as the quality of solvents and inorganics that you use. Now that the life science business of Merck KGaA, Darmstadt, Germany has brought together the exceptional knowledge, products, and capabilities of Merck Millipore and Sigma-Aldrich, you can trust that your results will have the sensitivity and reliability to shine.

HPLC Solvents & Reagents

In research and development, pharmaceutical quality control and environmental analysis HPLC requires high-performance solvents and reagents.

Our HPLC solvents are ideal for high-demanding and reproducible analysis with their high degree of UV transmittance, low particle count, low acidity & alkalinity and low evaporation residue level.

We offer LiChropur® reagents ideal for the HPLC analysis. These reagents are tested for inorganic impurities, including Al, Ca, Cu, Fe, K, Mg and Na.

• QC performed using a HPLC suitability gradient test at 220, 254 and 280 nm
• Filled under clean room conditions
• Extensive impurity profile of the product on the Certificate of Analysis

LCMS Solvents & Reagents

Our solvents meet all stringent requirements of LC-MS methods with highest resolution and sensitivity in LC-MS for best quantitative results. Thanks to its low level of ionic background and ion suppression, this quality ensures high ionisation efficiency.

We offer LiChropur® products specific for LC-MS analysis. These reagents are tested for inorganic impurities, including Al, Ca, Cu, Fe, K, Mg and Na.

• QC performed using a standard Reserpine test
• Filled under clean room conditions
• Extensive impurity profile of the product on the Certificate of Analysis

GC Solvents

Our GC solvent qualities are ideal for all gas chromatography applications. These solvents are specially developed and tested for ECD, FID and MS detection and show minimal signal-to-noise ratio in the largest specified retention time range.

Our solvents for headspace gas chromatography are developed particularly for the analysis of residual solvents in drug substances, excipients, and drug products according to Ph Eur and USP. Their high purity is provided by special designed production processes – for correct, reliable and reproducible results of analysis.

Solvents for Preparative Chromatography

Prepsolv® solvents are tailored to the requirements of preparative HPLC to facilitate scale-up from analytical to preparative separations.

• Low evaporation residue
• Low water content
• Optimal protection of columns
• High flexibility in pack size and supply concepts

Discover our complete portfolio on sigma-aldrich.com/brighter for:

• HPLC / LCMS
• Gas Chromatography
• Karl Fischer & Titration
• Elemental Trace Analysis
• Classical Analysis
• Safety & Essentials

Merck brings you:

Brighter Expertise

A global network of R&D, Manufacturing, and Quality Assurance combined with centuries of experience gives you the most up-to-date method development and documentation support for solvents & inorganics.

Brighter Solutions

Our close cooperation with our customers allows us to develop and support innovative solutions, not just products.

Brighter Convenience

Easy ordering on Sigma-Aldrich.com and our worldwide distribution organisation mean you can find the right solution and have it delivered the way you want it.