Manufacturer of Premium Chromatography Media

For more than a century MACHEREY-NAGEL stands for high quality, innovation and reliability in chemical and bioanalysis. The company is one of the leading manufacturers of products for separation science, filtration, water analysis and nucleic acid purification.

MACHEREY-NAGEL entered the ‘chromatography stage’ in the 1950s by launching filter papers for paper chromatography, an analytical method which today is commonly regarded as a kind of pre-historic TLC. From then on TLC became one of the main research areas of the company. MACHEREY-NAGEL started pioneering work in Thin-Layer-Chromatography and is still manufacturing glass plates, as well as aluminium and plastic sheets coated with silica gels and other sorbents for TLC and HPTLC. For more information, visit www.mn-net.com/TLC.

One decade later innovative chemists at MACHEREY-NAGEL developed NUCLEOSIL^®, one of the first spherical silica gels, intended to be packed in stainless steel columns for a young but emerging separation technology, named ‘HPLC’. NUCLEOSIL® columns with various C₁₈ modifications are still reliable workhorses and validated in many drug testing methods.

But this was just the beginning… In the recent years new highly pure and ultra-spherical HPLC and UHPLC silica gels followed. Today the product range of totally porous NUCLEODUR® and fused-core NUCLEOSHELL^® columns comprise more than 25 stationary phases, targeted to daily routine analysis as well as for method development in HPLC.

The NUCLEODUR^® portfolio includes robust RP phases such as the well-established C₁₈ Gravity or the extra polar C₁₈ Gravity-SB. C₁₈ Pyramid and C₁₈ PolarTec are qualified to withstand mobile phases with high water contents up to 100%. Columns with unique selectivities like Sphinx RP, pentafluorophenyl or hydrophilic HILIC round off the spectrum of innovative and modern HPLC phases. The recently introduced biphenyl phase NUCLEODUR® π², provides new options to improve selectivity for aromatic and unsaturated compounds.

In order to meet the growing demands on saving analysis time and solvent costs, MACHEREY-NAGEL expanded the program by adding core-shell silica phases with 2.7 and 5 µm particle size. NUCLEOSHELL^® reversed phase and HILIC columns enable significantly shorter run times at moderate column back pressures and set new efficiency standards in research and quality control. For more information, visit www.mn-net.com/HPLC.

A careful sample preparation is often a prerequisite for first class separation results. Classical CHROMABOND^® silica gel phases with various modifications (e.g. C₁₈, C₈, NH₂, OH, CN) and polymeric resins are widely used in environmental analysis, food safety control or clinical. The CHROMABOND^® HR-Xpert line of polystyrene-divinyl based RP and mixed-mode ion-exchange resins offers a full toolbox of innovative SPE products providing excellent recovery results of neutral, acidic and basic analytes. Columns for special applications, e.g. CHROMABOND^® Drug for drug analysis or CHROMABOND^® NAN for PCB analysis serve important application areas in forensic and environmental analysis. The latest launches CHROMABOND^® PL for the removal of phospholipids and CHROMABOND^® Carbon A for analysing acrylamide in drinking water supplement the steadily growing range of innovative SPE tools. For more information, visit www.mn-net.com/SPE.

MACHEREY-NAGEL provides comprehensive service and individual solutions for analytical separation tasks. The company operates worldwide through its own subsidiaries or with qualified and in-house trained distributors.

A wide range of applications are freely accessible online www.mn-net.com/apps.